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Therefore, it is an urgent issue to explore the underlying molecular mechanisms involved in the initiation and progression of ATC as a greater number of novel candidate targets are needed to improve treatment decisions

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However, when the S2 generation spheroids were treated with sulfasalazine, we observed a decreased expression of OCT-4 and NANOG, which are the major drivers of self-renewal ability in cancer stem cells, suggesting that the ferroptosis inducer, aside from inducing ferroptosis, is also capable of reducing the self-renewable potentiality of OCSCs and BCSCs